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Article

Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression.

Molecular systems biology - 1 Jan 2008

Yanai Itai, Baugh L Ryan, Smith Jessica J, Roehrig Casey, Shen-Orr Shai S, Claggett Julia M, Hill Andrew A, Slonim Donna K, Hunter Craig P

Abstract excerpt

Biological networks are inherently modular, yet little is known about how modules are assembled to enable coordinated and complex functions. We used RNAi and time series, whole-genome microarray analyses to systematically perturb and characterize components of a Caenorhabditis elegans lineage-specific transcriptional regulatory network. These data are supported by selected reporter gene analyses and comprehensive...

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Identifiers

PMID: 18277379
DOI: 10.1038/msb.2008.6
PMCID: PMC2267734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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