Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination.

doi:10.4161/cbt.7.5.5712

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Article

Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination.

Cancer biology & therapy - 1 May 2008

Berglind Hanna, Pawitan Yudi, Kato Shunsuke, Ishioka Chikashi, Soussi Thierry

Abstract excerpt

Cancer cell lines are essential tools used in many areas of biomedical research. Using the last release of the UMD_p53 database (2007) (http://p53.free.fr), we analysed the p53 status of 1,211 cell lines published between 1989 and 2007. p53 mutations in cell lines from various types of cancers display a striking similarity in the distribution of mutations and in the pattern of mutational events compared to...

Topics

Cell Culture Techniques
Cell Line, Tumor
Coculture Techniques
Codon
Databases, Genetic
Genes, p53
Genetic Variation
Humans
Mutation
Neoplasms
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 18277095
DOI: 10.4161/cbt.7.5.5712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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