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Article

Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.

Neuroscience - 18 Mar 2008

Clement A B, Hanstein R, Schröder A, Nagel H, Endres K, Fahrenholz F, Behl C

Abstract excerpt

A disintegrin and metalloprotease (ADAM) 10 is the main candidate enzyme for the alpha-secretase processing of the amyloid precursor protein (APP). Neuron-specific ADAM10 overexpression proved beneficial in the APP[V717I] mutant Alzheimer mouse model [Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz...

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Identifiers

PMID: 18276079
DOI: 10.1016/j.neuroscience.2007.10.060

Genes

ADAM10
APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.PMID 18276079Read ↗

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