Article
Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTP.
Molecular and cellular biology - 1 Apr 2005
Liu Hsuan, Peng Hsien-Wei, Cheng Yi-Sheng, Yuan Hanna S, Yang-Yen Hsin-Fang
Abstract excerpt
Mcl-1 is one Bcl-2 family member that plays a pivotal role in animal development. The extremely labile nature of the Mcl-1 protein itself and the fact that the Mcl-1 level is a critical determinant in various cell survival pathways suggest that cellular processes that regulate Mcl-1 stability are as important as those that regulate Mcl-1 synthesis. Although transcriptional stimulation of Mcl-1 synthesis in...
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