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Article

Variant form of STAT4 is associated with primary Sjögren's syndrome.

Genes and immunity - 1 Apr 2008

Korman B D, Alba M I, Le J M, Alevizos I, Smith J A, Nikolov N P, Kastner D L, Remmers E F, Illei G G

Abstract excerpt

Single nucleotide polymorphisms in the STAT4 gene have recently been shown to be associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Primary Sjögren's syndrome (pSS) is a related autoimmune disease thought to have a pathogenesis similar to these diseases. To test the...

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Source

Identifiers

PMID: 18273036
DOI: 10.1038/gene.2008.1

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18273036-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Variant form of STAT4 is associated with primary Sjögren's syndrome.PMID 18273036Read ↗

Genetics and epigenetics in primary Sjögren’s syndromeSemantic proximity Read ↗

Influence of STAT4 polymorphism in primary Sjögren's syndrome.Semantic proximity Read ↗

HIF1A (rs11549465) and AKNA (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren's Syndrome.Semantic proximity Read ↗

STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and could be involved in type 1 interferon pathway signaling.Semantic proximity Read ↗

Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

Common variants near IKZF1 are associated with primary Sjögren's syndrome in Han Chinese.Semantic proximity Read ↗

Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjögren's syndrome.Semantic proximity Read ↗

Association of STAT4 with rheumatoid arthritis: a replication study in three European populations.Semantic proximity Read ↗

A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor.Semantic proximity Read ↗

B-cell activating factor genetic variants in lymphomagenesis associated with primary Sjogren's syndrome.Semantic proximity Read ↗

Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome.Semantic proximity Read ↗

CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndrome.Semantic proximity Read ↗

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