Article
Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma.
Cancer science - 1 Feb 2008
Toyooka Shinichi, Takano Toshimi, Kosaka Takayuki, Hotta Katsuyuki, Matsuo Keitaro, Ichihara Shuji, Fujiwara Yoshiro, Soh Junichi, Otani Hiroki, Kiura Katsuyuki, Aoe Keisuke, Yatabe Yasushi, Ohe Yuichiro, Mitsudomi Tetsuya, Date Hiroshi
Abstract excerpt
Epidermal growth factor receptor (EGFR) mutations have been reported as a predictive factor for favorable prognosis of gefitinib-treated patients with lung adenocarcinoma. However, its confounding with sex and smoking makes it unclear whether the EGFR mutation is independently associated with prolonged patient survival. In this study, we analyzed a large-scale database to discriminate the survival impact of EGFR...
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