Article
Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design.
Genetic epidemiology - 1 May 2008
Sun Yan V, Bielak Lawrence F, Peyser Patricia A, Turner Stephen T, Sheedy Patrick F, Boerwinkle Eric, Kardia Sharon L R
Abstract excerpt
As part of the Genetic Epidemiology Network of Arteriopathy study, hypertensive non-Hispanic White sibships were screened using 471 single nucleotide polymorphisms (SNPs) to identify genes influencing coronary artery calcification (CAC) measured by computed tomography. Individuals with detectable CAC and CAC quantity > or =70th age- and sex-specific percentile were classified as having a high CAC burden and...
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