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Article

Genotype-driven identification of a molecular network predictive of advanced coronary calcium in ClinSeq® and Framingham Heart Study cohorts.

BMC systems biology - 26 Oct 2017

Oguz Cihan, Sen Shurjo K, Davis Adam R, Fu Yi-Ping, O'Donnell Christopher J, Gibbons Gary H

Abstract excerpt

BACKGROUND: One goal of personalized medicine is leveraging the emerging tools of data science to guide medical decision-making. Achieving this using disparate data sources is most daunting for polygenic traits. To this end, we employed random forests (RFs) and neural networks (NNs) for predictive modeling of coronary artery calcium (CAC), which is an intermediate endo-phenotype of coronary artery disease (CAD)....

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Identifiers

PMID: 29073909
DOI: 10.1186/s12918-017-0474-5
PMCID: PMC5659034

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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