Article
Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.
Diabetes - 1 Sept 2006
Das Swapan Kumar, Chu Winston S, Hale Terri C, Wang Xiaoqin, Craig Rebekah L, Wang Hua, Shuldiner Alan R, Froguel Philippe, Deloukas Panos, McCarthy Mark I, Zeggini Eleftheria, Hasstedt Sandra J, Elbein Steven C
Abstract excerpt
Linkage of type 2 diabetes to chromosome 1q21-q23 is well replicated across populations. In an initial 50-kb marker map (580 markers) across the linked region, one of the two strongest associations observed in Utah Caucasians was at marker rs1503814 (P < 0.00001 in pools, P < 0.004 in individuals). Based on this association, we typed additional markers and screened for sequence variation in the nearby DUSP12...
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