Article
Comprehensive evaluation of ESR2 variation and ovarian cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2008
Leigh Pearce Celeste, Near Aimee M, Butler Johannah L, Van Den Berg David, Bretsky Philip, Conti David V, Stram Daniel O, Pike Malcolm C, Hirschhorn Joel N, Wu Anna H
Abstract excerpt
Studies indicate that estrogen receptor beta, encoded by the ESR2 gene on chromosome 14q, may play a role in ovarian carcinogenesis. Using the genetic structure data generated by the Breast and Prostate Cohort Consortium (BPC3), we have comprehensively characterized the role of haplotype diversity in ESR2 and risk of ovarian cancer. Five haplotypes with a frequency of > or =5% were observed in White subjects and...
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