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Article

The lack of ESR1 ethnic diversity evidence and its implications for breast cancer personalized treatment.

Drug metabolism and personalized therapy - 1 Dec 2025

Manóchio Caíque, Faleiros Henrique, Vieira Jessica F, Oliveira-Ferreira Arthur, Nomelini Rosekeila S, Rodrigues-Soares Fernanda

Abstract excerpt

The ESR1 gene encodes estrogen receptor alpha (ERα), whose central role in breast tumorigenesis has supported the development of endocrine therapies, including selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs). Despite their proven efficacy, resistance, relapse, and treatment-limiting toxicity remain frequent, underscoring interindividual and interpopulation variability in therapeutic...

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Identifiers

PMID: 41247516
DOI: 10.1515/dmpt-2025-0067

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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The lack of ESR1 ethnic diversity evidence and its implications for breast cancer personalized treatment.PMID 41247516Read ↗

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Molecular characterization of ESR1 variants in breast cancer.Semantic proximity Read ↗

Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.Semantic proximity Read ↗

The Clinical Utility of ESR1 Mutations in Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer.Semantic proximity Read ↗

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.Semantic proximity Read ↗

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