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Article

Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility.

Antiviral research - 1 Oct 2020

Rabah Nadia, Ortega Granda Oney, Quérat Gilles, Canard Bruno, Decroly Etienne, Coutard Bruno

Abstract excerpt

Alphaviruses are arthropod-borne viruses of public health concern. To date no efficient vaccine nor antivirals are available for safe human use. During viral replication the nonstructural protein 1 (nsP1) catalyzes capping of genomic and subgenomic RNAs. The capping reaction is unique to the Alphavirus genus. The whole three-step process follows a particular order: (i) transfer of a methyl group from S-adenosyl...

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Share to Chikungunya virus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32750467
DOI: 10.1016/j.antiviral.2020.104883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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