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Article

Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis.

The Journal of investigative dermatology - 1 Aug 2008

Warren Richard B, Smith Rhodri L L, Campalani Emanuela, Eyre Steve, Smith Catherine H, Barker Jonathan N W N, Worthington Jane, Griffiths Christopher E M

Abstract excerpt

Methotrexate, an inexpensive first-line systemic therapy for moderate-to-severe psoriasis, is limited in its use by unpredictable efficacy and toxicity. This study was designed to test the hypothesis that single-nucleotide polymorphisms (SNPs) in methotrexate transmembrane transporters and adenosine receptors are associated with efficacy and/or toxicity of the drug. DNA was collected from 374 patients with...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18256692
DOI: 10.1038/jid.2008.16

Genes

ABCC1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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