Article
A promoter sequence variant of ZNF750 is linked with familial psoriasis.
The Journal of investigative dermatology - 1 Jul 2008
Yang Chi-Fan, Hwu Wuh-Liang, Yang Li-Cheng, Chung Wen-Hung, Chien Yin-Hsiu, Hung Chia-Fu, Chen Hung-Chih, Tsai Pei-Joung, Fann Cathy S J, Liao Fang, Chen Yuan-Tsong
Abstract excerpt
We previously mapped a psoriasis-susceptibility gene to a 3.8-Mb region of the 17q terminus in a five-generation Chinese family with autosomal-dominant psoriasis. To identify the mutations responsible for the psoriasis in this family, we sequenced 78 genes within the region and found four gene variants, p.Ala201Val in CD7, c.-625A>C in zinc-finger protein 750 (ZNF750), p.Asp189Asn in C17orf56, and p.Ala568Thr in...
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