Article
Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer.
Clinical chemistry and laboratory medicine - 1 Jan 2008
Li Dong-Ping, Dandara Collet, Walther Gabi, Parker M Iqbal
Abstract excerpt
BACKGROUND: Alcohol is a major risk factor for susceptibility to oesophageal cancer in the South African population. The role of polymorphisms in alcohol metabolising enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) in predisposition of this population to oesophageal cancer is unknown. Alcohol metabolising enzymes exhibit polymorphisms that result in variant alleles with either increased or...
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