Article
An inner membrane dioxygenase that generates the 2-hydroxymyristate moiety of Salmonella lipid A.
Biochemistry - 4 Mar 2008
Gibbons Henry S, Reynolds C Michael, Guan Ziqiang, Raetz Christian R H
Abstract excerpt
The lipid A residues of certain Gram-negative bacteria, including most strains of Salmonella and Pseudomonas, are esterified with one or two secondary S-2-hydroxyacyl chains. The S-2 hydroxylation process is O 2-dependent in vivo, but the relevant enzymatic pathways have not been fully characterized because in vitro assays have not been developed. We previously reported that expression of the Salmonella lpxO gene...
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