Article
Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages.
FEBS letters - 4 Jan 2010
Kawano Miyuki, Manabe Takayuki, Kawasaki Kiyoshi
Abstract excerpt
Modification of lipid A is essential for bacterial adaptation to its host. Salmonella Typhimurium LpxR potentially detoxifies lipid A by 3'-O-deacylation; however, the involvement of deacylation in its adaptation remains unclear. LpxR-dependent 3'-O-deacylation was observed in the stationary phase. When macrophages were infected with stationary phase bacteria, the intracellular growth of the lpxR-null strain was...
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