Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deregulated Protein Kinase A Signaling and Myospryn Expression in Muscular Dystrophy

6 Feb 2008

Abstract excerpt

Alterations in signaling pathway activity have been implicated in the pathogenesis of Duchenne muscular dystrophy, a degenerative muscle disease caused by a deficiency in the costameric protein dystrophin. Accordingly, the notion of the dystrophin-glycoprotein complex, and by extension the costamere, as harboring signaling components has received increased attention in recent years. The localization of most, if...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Genetic Neurodegenerative Diseases
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18252718
DOI: 10.1074/jbc.c700221200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deregulated Protein Kinase A Signaling and Myospryn Expression in Muscular DystrophyPMID 18252718Read ↗

Gαs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling.Semantic proximity Read ↗

Myospryn Is a Direct Transcriptional Target for MEF2A That Encodes a Striated Muscle, α-Actinin-interacting, Costamere-localized ProteinSemantic proximity Read ↗

Local protein kinase A signaling pathologies in the endocrine system.Semantic proximity Read ↗

The ties that bind: functional clusters in limb-girdle muscular dystrophySemantic proximity Read ↗

Intracellular Membrane Repair Dysregulation and Accumulation of Mature Myostatin Protein are Novel Markers of Muscle Pathophysiology in Pompe DiseaseSemantic proximity Read ↗

Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the RIβ-L50R variant is expressedSemantic proximity Read ↗

Myogenic Akt signaling upregulates the utrophin–glycoprotein complex and promotes sarcolemma stability in muscular dystrophySemantic proximity Read ↗

Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.Semantic proximity Read ↗

Identification and mapping of protein kinase A binding sites in the costameric protein myosprynSemantic proximity Read ↗

Probing muscle ankyrin-repeat protein (MARP) structure and function.Semantic proximity Read ↗

Defective autophagy and increased apoptosis contribute toward the pathogenesis of FKRP-associated muscular dystrophies.Semantic proximity Read ↗

Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.