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Article

Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.

American journal of human genetics - 1 Feb 2008

Wang Gaofeng, van der Walt Joelle M, Mayhew Gregory, Li Yi-Ju, Züchner Stephan, Scott William K, Martin Eden R, Vance Jeffery M

Abstract excerpt

Parkinson disease (PD) is a common neurodegenerative disorder caused by environmental and genetic factors. We have previously shown linkage of PD to chromosome 8p. Subsequently, fibroblast growth factor 20 (FGF20) at 8p21.3-22 was identified as a risk factor in several association studies. To identify the risk-conferring polymorphism in FGF20, we performed genetic and functional analysis of single-nucleotide...

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Source

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Identifiers

PMID: 18252210
DOI: 10.1016/j.ajhg.2007.09.021
PMCID: PMC2427225

Genes

FGF20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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