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Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson's Disease in Asian Population: A Meta-Analysis.

Genes - 29 Apr 2021

Chiang Han-Lin, Wu Yih-Ru, Chen Yi-Chun, Fung Hon-Chung, Chen Chiung-Mei

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disease with the pathological hallmark of Lewy bodies and Lewy neurites composed of α-synuclein. The SNP rs591323 is one of the risk loci located near the FGF20 gene that has been implicated in PD. The variation of FGF20 in the 3' untranslated region was shown to increase α-synuclein expression. We examined the association of rs591323 with the risk of PD in a...

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PMID: 33947140
DOI: 10.3390/genes12050674
PMCID: PMC8145858

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