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Article

Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping.

BMC genetics - 5 Feb 2008

Olshen Adam B, Gold Bert, Lohmueller Kirk E, Struewing Jeffery P, Satagopan Jaya, Stefanov Stefan A, Eskin Eleazar, Kirchhoff Tomas, Lautenberger James A, Klein Robert J, Friedman Eitan, Norton Larry, Ellis Nathan A, Viale Agnes, Lee Catherine S, Borgen Patrick I, Clark Andrew G, Offit Kenneth, Boyd Jeff

Abstract excerpt

BACKGROUND: Genetic isolates such as the Ashkenazi Jews (AJ) potentially offer advantages in mapping novel loci in whole genome disease association studies. To analyze patterns of genetic variation in AJ, genotypes of 101 healthy individuals were determined using the Affymetrix EAv3 500 K SNP array and compared to 60 CEPH-derived HapMap (CEU) individuals. 435,632 SNPs overlapped and met annotation criteria in the...

Topics

Chromosome Mapping
Female
Gene Frequency
Genetic Variation
Genotype
Haplotypes
Homozygote
Humans
Jews
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Principal Component Analysis

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Identifiers

PMID: 18251999
DOI: 10.1186/1471-2156-9-14
PMCID: PMC2259380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18251999-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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