Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population.

doi:10.1073/pnas.1004381107

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Article

Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population.

Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2010

Bray Steven M, Mulle Jennifer G, Dodd Anne F, Pulver Ann E, Wooding Stephen, Warren Stephen T

Abstract excerpt

The Ashkenazi Jewish (AJ) population has long been viewed as a genetic isolate, yet it is still unclear how population bottlenecks, admixture, or positive selection contribute to its genetic structure. Here we analyzed a large AJ cohort and found higher linkage disequilibrium (LD) and identity-by-descent relative to Europeans, as expected for an isolate. However, paradoxically we also found higher genetic...

Topics

Chromosomes, Human
Genetic Variation
Genetics, Population
Humans
Jews
Linkage Disequilibrium
Selection, Genetic

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Identifiers

PMID: 20798349
DOI: 10.1073/pnas.1004381107
PMCID: PMC2941333

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