Article
Implications for health and disease in the genetic signature of the Ashkenazi Jewish population.
Genome biology - 25 Jan 2012
Guha Saurav, Rosenfeld Jeffrey A, Malhotra Anil K, Lee Annette T, Gregersen Peter K, Kane John M, Pe'er Itsik, Darvasi Ariel, Lencz Todd
Abstract excerpt
BACKGROUND: Relatively small, reproductively isolated populations with reduced genetic diversity may have advantages for genomewide association mapping in disease genetics. The Ashkenazi Jewish population represents a unique population for study based on its recent (< 1,000 year) history of a limited number of founders, population bottlenecks and tradition of marriage within the community. We genotyped more than...
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