Article
Pathomechanisms of paraneoplastic myasthenia gravis.
Clinical & developmental immunology - 1 Mar 2003
Ströbel Philipp, Preisshofen Tobias, Helmreich Markus, Müller-Hermelink Hans Konrad, Marx Alexander
Abstract excerpt
Thymic T cell development is characterized by sequential selection processes to ensure generation of a self-tolerant, immuncompetent mature T cell repertoire. Malfunction of any of these selection processes may potentially result in either immunodeficiency or autoimmunity. Myasthenia gravis (MG) is a typical autoimmune manifestation of thymic epithelial tumors (thymomas) and is related to the capacity of these...
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