Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2008

Singh Ram Pyare, La Cava Antonio, Hahn Bevra H

Abstract excerpt

Systemic lupus erythematosus is an autoimmune disease caused primarily by autoantibodies (including IgG anti-DNA) and immune complexes that cause tissue damage. After tolerization with an artificial peptide (pConsensus, pCons) based on murine anti-DNA IgG sequences containing MHC class I and clas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Blocking
Share to Antigens, Surface
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Consensus Sequence

Share to Cytotoxicity, Immunologic

Share to Immune Tolerance

Share to Mice, Inbred NZB

Share to Programmed Cell Death 1 Receptor

Source

Identifiers

PMID: 18250412
DOI: 10.4049/jimmunol.180.4.2069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18250412-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules.PMID 18250412Read ↗

CD8+ T Cell-Mediated Suppression of Autoimmunity in a Murine Lupus Model of Peptide-Induced Immune Tolerance Depends on Foxp3 ExpressionSemantic proximity Read ↗

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.Semantic proximity Read ↗

Lupus resistance is associated with marginal zone abnormalities in an NZM murine model.Semantic proximity Read ↗

A peptide DNA surrogate accelerates autoimmune manifestations and nephritis in lupus-prone mice.Semantic proximity Read ↗

CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.Semantic proximity Read ↗

Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance.Semantic proximity Read ↗

Changes in the cytokine profile of lupus-prone mice (NZB/NZW)F1 induced by Plasmodium chabaudi and their implications in the reversal of clinical symptoms.Semantic proximity Read ↗

Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand.Semantic proximity Read ↗

Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.Semantic proximity Read ↗

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoireSemantic proximity Read ↗

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic toleranceSemantic proximity Read ↗

Treatment of Murine Lupus with CTLA4IgSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.