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Article

Mutations in Hydin impair ciliary motility in mice.

The Journal of cell biology - 11 Feb 2008

Lechtreck Karl-Ferdinand, Delmotte Philippe, Robinson Michael L, Sanderson Michael J, Witman George B

Abstract excerpt

Chlamydomonas reinhardtii hydin is a central pair protein required for flagellar motility, and mice with Hydin defects develop lethal hydrocephalus. To determine if defects in Hydin cause hydrocephalus through a mechanism involving cilia, we compared the morphology, ultrastructure, and activity of cilia in wild-type and hydin mutant mice strains. The length and density of cilia in the brains of mutant animals is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18250199
DOI: 10.1083/jcb.200710162
PMCID: PMC2234243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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