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Article

Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2020

Miyata Haruhiko, Shimada Keisuke, Morohoshi Akane, Oura Seiya, Matsumura Takafumi, Xu Zoulan, Oyama Yuki, Ikawa Masahito

Abstract excerpt

Kinesin is a molecular motor that moves along microtubules. Kinesin family member 9 (KIF9) is evolutionarily conserved and expressed strongly in mouse testis. In the unicellular flagellate Chlamydomonas, KLP1 (ortholog of KIF9) is localized to the central pair microtubules of the axoneme and regulates flagellar motility. In contrast, the function of KIF9 remains unclear in mammals. Here, we mutated KIF9 in mice...

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Identifiers

PMID: 32072696
DOI: 10.1096/fj.201902755R
PMCID: PMC7136151

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