The hydrocephalus inducing gene product, Hydin, positions axonemal central pair microtubules

Abstract excerpt

BACKGROUND: Impairment of cilia and flagella function underlies a growing number of human genetic diseases. Mutations in hydin in hy3 mice cause lethal communicating hydrocephalus with early onset. Hydin was recently identified as an axonemal protein; however, its function is as yet unknown. RESULTS: Here we use RNAi in Trypanosoma brucei to address this issue and demonstrate that loss of Hydin causes slow growth...

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