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Article

Common 677C-->T mutation of the 5,10-methylenetetrahydrofolate reductase gene affects follicular estradiol synthesis.

Fertility and sterility - 1 Jan 2009

Hecht Stephanie, Pavlik Roman, Lohse Peter, Noss Ulrich, Friese Klaus, Thaler Christian J

Abstract excerpt

OBJECTIVE: To investigate the influence of the 5,10-methylenetetrahydrofolate reductase 677C-->T mutation on the E(2) synthesis in human granulosa cells (GCs). DESIGN: In vitro cell culture study. SETTING: Research laboratory of a university hospital. PATIENT(S): Follicular fluids (n = 139) and GCs (n = 66) were obtained from patients undergoing controlled ovarian hyperstimulation for IVF with or without ICSI....

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PMID: 18249399
DOI: 10.1016/j.fertnstert.2007.11.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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