Article
Effects of the FSH receptor gene polymorphism p.N680S on cAMP and steroid production in cultured primary human granulosa cells.
Reproductive biomedicine online - 1 Aug 2011
Nordhoff Verena, Sonntag Barbara, von Tils Dominik, Götte Martin, Schüring Andreas N, Gromoll Jörg, Redmann Klaus, Casarini Livio, Simoni Manuela
Abstract excerpt
The study was designed to evaluate in vitro the cellular mechanisms of the single nucleotide polymorphism (SNP) p.N680S of the FSH receptor gene (FSHR) in human granulosa cells (GC) and included patients homozygous for the FSHR SNP (NN/SS) undergoing ovarian stimulation. GC were isolated during oocyte retrieval and cultured for 1–7 days. Basal oestradiol and progesterone concentrations were measured after...
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