Adenovirus type 5 E3 gene products interfere with the expression of the cytolytic T cell immunodominant E1a antigen.

doi:10.1016/0042-6822(91)90024-6

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Article

Adenovirus type 5 E3 gene products interfere with the expression of the cytolytic T cell immunodominant E1a antigen.

Virology - 1 Jan 1991

Zhang X L, Bellett A J, Hla R T, Braithwaite A W, Müllbacher A

Abstract excerpt

Effects of mutations in the adenovirus 5 (Ad 5) E3 transcription unit on the immune Tc cell response to Ad 5 were investigated. We observed enhanced lysis of L929 target cells infected with the E3 defective mutant viruses dl 327 and dl 355 compared to wild-type (wt) Ad 5 by Ad 5 immune Tc cells. This enhanced lysability was not due to E3 effects on the cell surface expression of class I MHC H-2Kk molecules as...

Topics

Adenovirus Early Proteins
Adenoviruses, Simian
Animals
Antibodies, Monoclonal
Antigens, Viral
Cytotoxicity, Immunologic
Genes, Viral
H-2 Antigens
Immunodominant Epitopes
Mice
Mice, Inbred CBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Proteins, Viral

RNA, Messenger

RNA, Viral

T-Lymphocytes, Cytotoxic

Transcription, Genetic

Vaccinia virus

Source

Open in PubMed

Identifiers

PMID: 1824606
DOI: 10.1016/0042-6822(91)90024-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1824606-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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