The flavivirus nonstructural protein NS3 is a dominant source of cytotoxic T cell peptide determinants.

doi:10.1006/viro.1994.1335

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Article

The flavivirus nonstructural protein NS3 is a dominant source of cytotoxic T cell peptide determinants.

Virology - 1 Jul 1994

Lobigs M, Arthur C E, Müllbacher A, Blanden R V

Abstract excerpt

Vaccinia virus recombinants encoding regions of the Murray Valley encephalitis virus (MVE) genome, which together cover the entire viral coding region, were employed to identify the MVE protein which is the dominant source of CD8+, cytotoxic, T cell antigenic determinant(s) presented by the mouse H-2Kk major histocompatibility antigen. MVE and West Nile virus-immune, H-2k-restricted, effector cells recognized...

Topics

Alleles
Animals
Antigen Presentation
Antigens, Viral
Base Sequence
Cross Reactions
DNA, Viral
Encephalitis Virus, Murray Valley
Epitopes
Major Histocompatibility Complex
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Protein Processing, Post-Translational

RNA Helicases

RNA, Viral

Serine Endopeptidases

T-Lymphocytes, Cytotoxic

Viral Nonstructural Proteins

Source

Open in PubMed

Identifiers

PMID: 7516597
DOI: 10.1006/viro.1994.1335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7516597-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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