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Article

Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease.

Neurobiology of disease - 1 Apr 2008

Botella Jose A, Bayersdorfer Florian, Schneuwly Stephan

Abstract excerpt

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Some of the inherited forms of the disease are caused by mutations in the alpha-synuclein gene and the triplication of its locus. Oxidative stress has been proposed as a central mechanism for the progression of the disease although its relation with alpha-synuclein toxicity remains...

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PMID: 18243716
DOI: 10.1016/j.nbd.2007.11.013

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