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Article

Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models.

Free radical biology & medicine - 1 Jul 2017

Sanz Francisco José, Solana-Manrique Cristina, Muñoz-Soriano Verónica, Calap-Quintana Pablo, Moltó María Dolores, Paricio Nuria

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. It is caused by a loss of dopaminergic neurons in the substantia nigra pars compacta, leading to a decrease in dopamine levels in the striatum and thus producing movement impairment. Major physiological causes of neurodegeneration in PD are oxidative stress (OS) and mitochondrial dysfunction; these...

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PMID: 28455141
DOI: 10.1016/j.freeradbiomed.2017.04.364

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