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Article

A double mutation in glycoprotein gB compensates for ineffective gD-dependent initiation of herpes simplex virus type 1 infection.

Journal of virology - 1 Dec 2010

Uchida Hiroaki, Chan Janet, Goins William F, Grandi Paola, Kumagai Izumi, Cohen Justus B, Glorioso Joseph C

Abstract excerpt

Herpes simplex virus (HSV) entry into cells is triggered by the binding of envelope glycoprotein D (gD) to a specific receptor, such as nectin-1 or herpesvirus entry mediator (HVEM), resulting in activation of the fusion effectors gB and gH and virus penetration. Here we report the identification of a hyperactive gB allele, D285N/A549T, selected by repeat passage of a gD mutant virus defective for nectin-1...

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Source

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Identifiers

PMID: 20861246
DOI: 10.1128/JVI.01633-10
PMCID: PMC2976401

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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