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Article

Denaturing high-performance liquid chromatography mutation analysis in patients with reduced Protein S levels.

Clinica chimica acta; international journal of clinical chemistry - 1 Apr 2008

Bathum Lise, Münster Anna-Marie, Nybo Mads, Madsen Jonna Skov, Larsen Torben Bjerregaard, Kristensen Søren Risom

Abstract excerpt

BACKGROUND: Patients with congenital Protein S deficiency have increased risk of venous thromboembolism. However, Protein S levels show large intra-individual variation and the biochemical assays have low accuracy and a high interlaboratory variability. Genetic analysis might aid in a more precise diagnosis and risk estimation. The aim was to design a high-throughput genetic analysis based on denaturing...

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PMID: 18242167
DOI: 10.1016/j.cca.2007.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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