Article
Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect.
Annals of internal medicine - 1 Jan 1998
Simmonds R E, Ireland H, Lane D A, Zöller B, García de Frutos P, Dahlbäck B
Abstract excerpt
BACKGROUND: Protein S is an important regulatory protein of the coagulation cascade. The risk for venous thrombosis associated with protein S deficiency has been uncertain because all previous risk estimates used phenotypic evaluation alone, which can be ambiguous. OBJECTIVE: To quantitate the ri...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Chi-Square Distribution
- Child
- Disease-Free Survival
- Female
- Heterozygote
- Humans
- Male
- Middle Aged
- Mutation
- Phenotype
- Protein S Deficiency
- Regression Analysis
- Risk Factors
- Thrombophlebitis