Article
Development of aberrant crypt foci in the colons of ob/ob and db/db mice: evidence that leptin is not a promoter.
Molecular carcinogenesis - 1 Sept 2008
Ealey Kafi N, Lu Suying, Archer Michael C
Abstract excerpt
Leptin is elevated in obesity and has been suggested to increase the risk of colorectal cancer (CRC), although the evidence is conflicting. The objective of this study was to compare the susceptibility to colon carcinogenesis of db/db mice that have highly elevated circulating leptin and leptin-deficient ob/ob mice, both of which are obese. Seven-week-old male ob/ob, db/db, and WT mice received 4 weekly i.p....
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