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Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc.

Carcinogenesis - 1 Jul 2016

Wang Hong, Liu Anna, Kuo Yingyi, Chi Eric, Yang Xu, Zhang Lanjing, Yang Chung S

Abstract excerpt

Obesity is associated with an increased risk of cancer. To study the promotion of dietary carcinogen-induced gastrointestinal cancer by obesity, we employed 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to induce intestinal tumorigenesis in CYP1A-humanized (hCYP1A) mice, in which mouse Cyp1a1/1a2 was replaced with human CYP1A1/1A2 Obesity was introduced in hCYP1A mice by breeding with Lepr(db/+) mice to...

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Identifiers

PMID: 27207656
DOI: 10.1093/carcin/bgw054
PMCID: PMC4936388

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