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Article

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.

Arthritis and rheumatism - 1 Feb 2008

Chen Yunliang, Leask Andrew, Abraham David J, Pala Daphne, Shiwen Xu, Khan Korsa, Liu Shangxi, Carter David E, Wilcox-Adelman Sarah, Goetinck Paul, Denton Christopher P, Black Carol M, Pitsillides Andrew A, Sarraf Catherine E, Eastwood Mark

Abstract excerpt

OBJECTIVE: To investigate the contribution of heparan sulfate proteoglycan and Ras/MEK/ERK to the overexpression of profibrotic proteins and the enhanced contractile ability of dermal fibroblasts from patients with systemic sclerosis (SSc; scleroderma). METHODS: The effects of the MEK/ERK inhibitor U0126, the heparan sulfate side chain formation inhibitor beta-xyloside, and soluble heparin on the overexpression...

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Identifiers

PMID: 18240216
DOI: 10.1002/art.23146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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