Article
Association of common variants in JAK2 gene with reduced risk of metabolic syndrome and related disorders.
BMC medical genetics - 20 Dec 2011
Penas-Steinhardt Alberto, Tellechea Mariana L, Gomez-Rosso Leonardo, Brites Fernando, Frechtel Gustavo D, Poskus Edgardo
Abstract excerpt
BACKGROUND: Disturbances in leptin and insulin signaling pathways are related to obesity and metabolic syndrome (MS) with increased risk of diabetes and cardiovascular disease. Janus kinase 2 (JAK2) is a tyrosine kinase involved in the activation of mechanisms that mediate leptin and insulin actions. We conducted a population cross-sectional study to explore the association between two common variants in JAK2...
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