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Article

Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects.

Developmental biology - 15 Jan 2007

Jay Patrick Y, Bielinska Malgorzata, Erlich Jonathan M, Mannisto Susanna, Pu William T, Heikinheimo Markku, Wilson David B

Abstract excerpt

Congenital diaphragmatic hernia (CDH) is an often fatal birth defect that is commonly associated with pulmonary hypoplasia and cardiac malformations. Some investigators hypothesize that this constellation of defects results from genetic or environmental triggers that disrupt mesenchymal cell function in not only the primordial diaphragm but also the thoracic organs. The alternative hypothesis is that the...

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Share to GATA4 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Developmental

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Share to Hernias, Diaphragmatic, Congenital

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Source

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Identifiers

PMID: 17069789
DOI: 10.1016/j.ydbio.2006.09.050
PMCID: PMC1808541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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