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Article

Strong purifying selection in transmission of mammalian mitochondrial DNA.

PLoS biology - 1 Jan 2008

Stewart James Bruce, Freyer Christoph, Elson Joanna L, Wredenberg Anna, Cansu Zekiye, Trifunovic Aleksandra, Larsson Nils-Göran

Abstract excerpt

There is an intense debate concerning whether selection or demographics has been most important in shaping the sequence variation observed in modern human mitochondrial DNA (mtDNA). Purifying selection is thought to be important in shaping mtDNA sequence evolution, but the strength of this selection has been debated, mainly due to the threshold effect of pathogenic mtDNA mutations and an observed excess of new...

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Identifiers

PMID: 18232733
DOI: 10.1371/journal.pbio.0060010
PMCID: PMC2214808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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