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Article

Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system.

Journal of bacteriology - 1 Jun 1996

Brian P, Riggle P J, Santos R A, Champness W C

Abstract excerpt

Streptomycete antibiotic synthesis is coupled to morphological differentiation such that antibiotics are produced as a colony sporulates. Streptomyces coelicolor produces several structurally and genetically distinct antibiotics. The S. coelicolor absA locus was defined by four UV-induced mutations that globally blocked antibiotic biosynthesis without blocking morphological differentiation. We show that the absA...

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Identifiers

PMID: 8655502
DOI: 10.1128/jb.178.11.3221-3231.1996
PMCID: PMC178074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system.PMID 8655502Read ↗

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Biochemical activities of the absA two-component system of Streptomyces coelicolor.Semantic proximity Read ↗

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