Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system.

doi:10.1128/jb.178.11.3221-3231.1996

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Article

Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system.

Journal of bacteriology - 1 Jun 1996

Brian P, Riggle P J, Santos R A, Champness W C

Abstract excerpt

Streptomycete antibiotic synthesis is coupled to morphological differentiation such that antibiotics are produced as a colony sporulates. Streptomyces coelicolor produces several structurally and genetically distinct antibiotics. The S. coelicolor absA locus was defined by four UV-induced mutatio...

Topics

Alleles
Amino Acid Sequence
Anthraquinones
Anti-Bacterial Agents
Base Sequence
Chromosome Mapping
Cloning, Molecular
Genes, Bacterial
Molecular Sequence Data
Mutation
Signal Transduction
Streptomyces

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