Article
Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2008
Shi Jiajun, Wittke-Thompson Jacqueline K, Badner Judith A, Hattori Eiji, Potash James B, Willour Virginia L, McMahon Francis J, Gershon Elliot S, Liu Chunyu
Abstract excerpt
Several previous studies suggest that dysfunction of circadian rhythms may increase susceptibility to bipolar disorder (BP). We conducted an association study of five circadian genes (CRY2, PER1-3, and TIMELESS) in a family collection of 36 trios and 79 quads (Sample I), and 10 circadian genes (ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CSNK1D, CSNK1E, DBP, and NR1D1) in an extended family collection of 70 trios...
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