Article
Testing the role of circadian genes in conferring risk for psychiatric disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2014
Byrne Enda M, Heath Andrew C, Madden Pamela A F, Pergadia Michele L, Hickie Ian B, Montgomery Grant W, Martin Nicholas G, Wray Naomi R
Abstract excerpt
Disturbed sleep and disrupted circadian rhythms are a common feature of psychiatric disorders, and many groups have postulated an association between genetic variants in circadian clock genes and psychiatric disorders. Using summary data from the association analyses of the Psychiatric Genomics Consortia (PGC) for schizophrenia, bipolar disorder and major depressive disorder, we evaluated the evidence that common...
Topics
- Bipolar Disorder
- CLOCK Proteins
- Circadian Clocks
- Depressive Disorder, Major
- Genetic Predisposition to Disease
- Humans
- Polymorphism, Single Nucleotide
- Schizophrenia