Article
Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa.
Therapeutic drug monitoring - 1 Feb 2008
Ferreira Pedro Eduardo, Veiga Maria Isabel, Cavaco Isa, Martins J Paulo, Andersson Björn, Mushin Shaliya, Ali Abullah S, Bhattarai Achuyt, Ribeiro Vera, Björkman Anders, Gil José Pedro
Abstract excerpt
Artemisinin-based combination therapy is a main strategy for malaria control in Africa. Zanzibar introduced this new treatment policy in 2003. The authors have studied the prevalence of a number of functional single nucleotide polymorphisms (SNPs) in genes associated with the elimination of the artemisinin-based combination therapy compounds in use in Zanzibar to investigate the frequencies of subgroups...
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