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Article

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality.

Blood - 15 Mar 2008

Jasperson Lisa K, Bucher Christoph, Panoskaltsis-Mortari Angela, Taylor Patricia A, Mellor Andrew L, Munn David H, Blazar Bruce R

Abstract excerpt

Graft-versus-host disease (GVHD) is initiated after activation of donor T cells by host antigen-presenting cells (APCs). The immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by APCs and parenchymal cells and is further inducible by inflammation. We investigated whether lethal conditioning and GVHD induce IDO and if IDO prevents tissue injury by suppressing immune responses at the induction...

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Source

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Identifiers

PMID: 18077788
DOI: 10.1182/blood-2007-06-096081
PMCID: PMC2265461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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