Article
Development of a human mitochondrial oligonucleotide microarray (h-MitoArray) and gene expression analysis of fibroblast cell lines from 13 patients with isolated F1Fo ATP synthase deficiency.
BMC genomics - 25 Jan 2008
Cízková Alena, Stránecký Viktor, Ivánek Robert, Hartmannová Hana, Nosková Lenka, Piherová Lenka, Tesarová Markéta, Hansíková Hana, Honzík Tomás, Zeman Jirí, Divina Petr, Potocká Andrea, Paul Jan, Sperl Wolfgang, Mayr Johannes A, Seneca Sara, Houstĕk Josef, Kmoch Stanislav
Abstract excerpt
BACKGROUND: To strengthen research and differential diagnostics of mitochondrial disorders, we constructed and validated an oligonucleotide microarray (h-MitoArray) allowing expression analysis of 1632 human genes involved in mitochondrial biology, cell cycle regulation, signal transduction and apoptosis. Using h-MitoArray we analyzed gene expression profiles in 9 control and 13 fibroblast cell lines from...
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