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Whole blood genome-wide expression profiling and network analysis suggest MELAS master regulators.

Neurological research - 1 Jul 2011

Mende Susanne, Royer Loic, Herr Alexander, Schmiedel Janet, Deschauer Marcus, Klopstock Thomas, Kostic Vladimir S, Schroeder Michael, Reichmann Heinz, Storch Alexander

Abstract excerpt

BACKGROUND: The heteroplasmic mitochondrial DNA (mtDNA) mutation A3243G causes the mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome as one of the most frequent mitochondrial diseases. The process of reconfiguration of nuclear gene expression profile to accommodate cellular processes to the functional status of mitochondria might be a key to MELAS disease manifestation...

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PMID: 21708074
DOI: 10.1179/1743132810Y.0000000016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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